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Table 2 Common transcriptional factors for proteomics and expression datasets

From: Integrated network analysis of transcriptomic and proteomic data in psoriasis

Transcriptomics

Proteomics

Entrez ID

Gene

Over-connection P-Value

Hidden nodes P-Value

Entrez ID

Gene

Over-connection P-Value

Hidden nodes P-Value

6772

STAT1

4.081E-28

1.027E-22

2736

GLI2

4.318E-03

2.080E-04

3659

IRF1

1.344E-22

3.203E-19

6772

STAT1

2.234E-04

1.293E-04

4790

NFKB1

3.677E-13

2.523E-25

3091

HIF1A

2.345E-03

2.402E-04

5970

RELA

3.726E-14

4.120E-24

6778

STAT6

9.420E-04

2.080E-04

5966

REL

4.844E-17

3.580E-16

7392

USF2

1.507E-04

-

6688

SPI1

7.019E-13

1.245E-16

6774

STAT3

2.542E-05

-

3394

IRF8

7.594E-12

1.903E-16

6776

STAT5A

-

2.820E-05

1051

CEBPB

1.590E-12

1.271E-15

668

FOXL2

1.100E-02

1.388E-03

2908

NR3C1

2.307E-05

1.504E-17

2078

ERG

2.386E-04

1.388E-03

10379

IRF9

8.193E-05

4.037E-17

6777

STAT5B

-

2.820E-05

3660

IRF2

3.794E-12

3.914E-09

7020

TFAP2A

4.806E-04

-

6434

SFRS10

-

4.420E-17

5371

PML

1.177E-03

-

6775

STAT4

1.637E-03

5.842E-16

2735

GLI1

1.053E-02

-

6667

SP1

5.508E-12

2.013E-07

6667

SP1

3.269E-05

-

6777

STAT5B

2.725E-04

2.063E-15

3725

JUN

1.198E-03

-

3725

JUN

2.182E-11

7.521E-11

8462

KLF11

6.710E-03

2.775E-03

6774

STAT3

9.643E-10

2.114E-11

2099

ESR1

1.650E-02

-

7157

TP53

9.352E-10

7.171E-08

10538

BATF

1.765E-02

-

30009

TBX21

5.119E-03

1.594E-14

30009

TBX21

-

1.911E-04

1874

E2F4

1.537E-09

8.737E-07

7421

VDR

-

1.693E-04

Additional TFs identified by subnetwork-based analysis

4609

MYC

2.680E-69

-

4609

MYC

1.120E-07

-

    

5966

REL

1.120E-07

-

    

5970

RELA

1.120E-07

-

    

4790

NFKB1

1.120E-07

-

  1. Some genes were considered significant only by one of two topological approaches (this is evident for proteomics data, where low number of proteins limits capabilities of topological analysis). Missing p-value means that correspondent gene has not passed 0.05 significance threshold and has been listed among top factors only due to low p-value for other topological approach. Only one p-value was determined in the case of network analysis (enrichment p-value for the network built around seed transcription factor). Transcriptional factors common for proteomics and transcriptomics level are in bold text.