TY - JOUR AU - Shibeko, Alexey M. AU - Lobanova, Ekaterina S. AU - Panteleev, Mikhail A. AU - Ataullakhanov, Fazoil I. PY - 2010 DA - 2010/01/26 TI - Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa JO - BMC Systems Biology SP - 5 VL - 4 IS - 1 AB - Blood coagulation is a complex network of biochemical reactions, which is peculiar in that it is time- and space-dependent, and has to function in the presence of rapid flow. Recent experimental reports suggest that flow plays a significant role in its regulation. The objective of this study was to use systems biology techniques to investigate this regulation and to identify mechanisms creating a flow-dependent switch in the coagulation onset. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-4-5 DO - 10.1186/1752-0509-4-5 ID - Shibeko2010 ER -