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Figure 2 | BMC Systems Biology

Figure 2

From: Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa

Figure 2

Dependence of lagtime on flow shear rate at different fibrin gelation parameters. (a) Lagtime dependence is quantitatively, but not qualitatively influenced by the fibrin gelation point. In most simulations, we used fibrin concentration of 450 nM as a point of gelation (black). Here we show that increase of this value up to 760 nM (red) reduces range of flow rates, where coagulation resists flow, but the overall effect of flow does not change. Decreasing the value of fibrin gelation point down to 380 nM (blue) prolongs this range. (b) Lagtime is not influenced by the of choice concentration, where we assume fibrin to form a solid clot. Throughout the study, we used value of 3,800 nM. This figure shows the changing this value has no effect.

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