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Table 1 Effect of system perturbation on sensitivity to flow

From: Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa

Condition R'
   i-j, s -1  
Control, Fn gel concentration 380 nM 0.76 0-28 0.81
Control, Fn gel concentration 760 nM 2.72 0-20 2.05
Control, Fn concentration of solid clot 450 nM 0.97 0-28 1
Control, Fn concentration of solid clot 7600 nM 1.02 0-28 1.01
Control 1 0-28 1
Control (activator size 500 μm) 3.351 0-15 2.11
No convection of zymogens 1.03 0-28 1
No convection of enzymes 0 0-28 -
No convection of enzymes except for IIa & Xa 0.392 0-15 0.632
No convection of IIa & Xa 0.01 0-28 -
No Xa-induced VII-TF activation 7.73 0-12 0.33
No IIa-induced activation of V, VII, VIII, XI 1.72 0-12 1.12
Addition of TFPI at 5 nM 5.55 0-12 4.5
Addition of AT-III at 6800 nM 1.38 0-24 1.22
Addition of VIIa at 10 nM 0.07 0-24 0.25
  1. Table 1 indicates how perturbations of the coagulation system alter its behavior (length of coagulation onset) under flow conditions. Two coefficients represent two different types of flow induced influence on this system (see Methods). shows whether system is suppressed by flow (within range of flow rates from i s-1 up to j s-1) better or worth than in normal case ( > 1 or < 1). Each set of simulation results was approximated, where it was possible, with exponential function of the following type: y = y0 + A·eR·x. Parameter R' shows whether system became more sensitive to flow rate variation than in normal case (R' > 1 or R' < 1).
  2. 1 Coefficient calculated relatively to normal case (1000 um activator length)
  3. 2 Coefficient calculated relatively to normal case (500 um activator length)
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