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Table 1 Comparison of reactions inhibited by drugs in original and simplified systems.

From: A formal model for analyzing drug combination effects and its application in TNF-α-induced NFκB pathway

Inhibitors

Corresponding reactions

in original system

Corresponding reactions

in simplified system

Geldanamycin

RIP1 binding with TNFR1 complex

IKKK-P activates IKK-β

PS-1145

IKK-β-P phosphorylates IκB

IKK-β-P phosphorylates IκB

Aldehyde

IκB degradation

IκB degradation

  1. In the simulation, we simplified the system according to Lemma 1. Here we list the corresponding reactions inhibited by the three inhibitors in original and simplified systems.
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BMC Systems Biology

ISSN: 1752-0509

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