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Table 1 Comparison of reactions inhibited by drugs in original and simplified systems.

From: A formal model for analyzing drug combination effects and its application in TNF-α-induced NFκB pathway

Inhibitors Corresponding reactions
in original system
Corresponding reactions
in simplified system
Geldanamycin RIP1 binding with TNFR1 complex IKKK-P activates IKK-β
PS-1145 IKK-β-P phosphorylates IκB IKK-β-P phosphorylates IκB
Aldehyde IκB degradation IκB degradation
  1. In the simulation, we simplified the system according to Lemma 1. Here we list the corresponding reactions inhibited by the three inhibitors in original and simplified systems.