Differential expression of microRNA and mRNA between normal and tumor tissue. A. Heatmap of 35 microRNA differentially expressed in ccRCC and matched normal kidney tissue in the primary dataset. B. Heatmap of some of the identified mRNA targets of the microRNA in A as identified by our method. C. Heatmap of the 27 microRNA in A which were available on the Agilent chipset used on the validation samples. D. Validation sample set heatmap of mRNA levels for the same genes as in B.