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Table 1 OptORF formulation

From: OptORF: Optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains

maximize

biochemical production

subject to

  
 

maximize

cellular growth

 

subject to

steady-state mass balance

  

enzyme capacity

  

thermodynamics

  

reaction deletions

 

GPR associations

 

transcriptional regulations

 

gene deletions and overexpressions

 

limited number of gene deletions

 

limited number of gene overexpressions