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Table 1 OptORF formulation

From: OptORF: Optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains

maximize biochemical production
subject to   
  maximize cellular growth
  subject to steady-state mass balance
   enzyme capacity
   thermodynamics
   reaction deletions
  GPR associations
  transcriptional regulations
  gene deletions and overexpressions
  limited number of gene deletions
  limited number of gene overexpressions