Figure 3

Flux control coefficients. The colors in row i and column j indicate the control that enzyme j exerts over the steady flux i. Warm and cold colors denote positive and negative control, respectively. The indices i and j correspond to the reaction numbers shown in Table 1 and Figure 1. The glucose-6-phosphate dehydrogenase (r10) was found to have significant negative control over all glycolytic fluxes, whereas oxidative phosphorylation (r41) exerted positive control (Warburg effect). Furthermore, it is interesting to note that only a few fluxes were found to be significantly stimulated by an increase in the corresponding enzyme level.