From: Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells
 |  | Stoichiometry | |
---|---|---|---|
Reaction number | Reaction name | Substrates | Products |
r1 | glucokinase | GLCin + ATPin | G6Pin + ADPin + Hnb |
r2 | glucose-6-phosphate isomerase | G6Pin | F6Pin |
r3 | phosphofructokinase | F6Pin + ATPin | F16Pin + ADPin + Hnb |
r4 | fructose-bisphosphate aldolase | F16Pin | DHAPin + GAPin |
r5 | triose-phosphate isomerase | DHAPin | GAPin |
r6 | glyceraldehyde-3-phosphate dehydrogenase | GAPin + Pnb + NADin | 13PGin + NADHin + Hnb |
r7 | phosphoglycerate kinase | 13PGin + ADPin + Hnb | G3Pin + ATPin |
r8 | phosphoglycerate mutase | G3Pin | G2Pin |
r9 | pyruvate kinase | PEPin + ADPin + Hnb | PYRin + ATPin |
r10 | glucose-6-phosphate dehydrogenase | G6Pin + NADPin | GL6Pin + NADPHin + Hnb |
r11 | 6-phosphogluconolactonase | GL6Pin + H2Onb | 6GPin + Hnb |
r12 | phosphogluconate dehydrogenase | 6GPin + NADPin | RIBU5Pin + CO2nb + NADPHin |
r13 | ribose-5-phosphate isomerase | RIBU5Pin | RIBO5Pin |
r14 | ribulose-phosphate 3-epimerase | RIBU5Pin | XYL5Pin |
r15 | transketolase | RIBO5Pin + XYL5Pin | GAPin + S7Pin |
r16 | transketolase | XYL5Pin + E4Pin | GAPin + F6Pin |
r17 | phosphopyruvate hydratase | G2Pin | PEPin + H2Onb + Hnb |
r18 | lactate dehydrogenase | PYRin + NADHin + Hnb | LACin + NADin |
r19 | adenosinetriphosphatase | ATPin + H2Onb | ADPin + Pnb + Hnb |
r20 | alanine transaminase | ALAin + AKGin | PYRin + GLUin |
r21 | phosphoglucomutase | G6Pin | G1Pin |
r22 | nadph consumption | NADPHin + Anb | NADPin + AHnb |
r23 | glycogen synthesis | UTPnb + G1Pin | UDPnb + GLYGnb + Hnb + PPnb |
r24 | transaldolase | S7Pin + GAPin | F6Pin + E4Pin |
r25 | adenylate kinase | ATPin + AMPin | 2·ADPin |
r26 | glycerol synthesis | DHAPin | GLYCEROLnb |
r27 | nucleotide synthesis | RIBO5Pin + ATPin | PRPPin + AMPin + Hnb |
r28 | serine synthesis | G3Pin + NADin + GLUin + H2Onb | SERin + Pnb + NADHin + 2·Hnb + AKGin |
r29 | citrate synthase | OACin + ACCOAin + H2Onb | CITin + COAin + Hnb |
r30 | aconitate hydratase | CITin | CISACin + H2Onb |
r31 | aconitate hydratase | CISACin + H2Onb | ISOCITin |
r32 | isocitrate dehydrogenase | ISOCITin + NADin | AKGin + CO2nb + NADHin |
r33 | succinate-CoA ligase | SUCCOAin + Pnb + ADPin | SUCin + COAnb + ATPin |
r34 | fumarate hydratase | FUMin + H2Onb | MALin |
r35 | malate dehydrogenase | MALin + NADin | OACin + NADHin + Hnb |
r36 | pyruvate dehydrogenase complex | PYRin + NADin + COAnb | CO2nb + NADHin + ACCOAin |
r37 | alpha-ketoglutarate dehydrogenase complex | AKGin + NADin + COAnb | SUCCOAin + CO2nb + NADHin |
r38 | pyruvate synthesis | PYRnb | PYRin |
r39 | valine leucine isoleucine metabolism | ISOVALMETnb | SUCCOAin |
r40 | succinate dehydrogenase | SUCin + 0.6·NADin +0.2·O2nb | FUMin + 0.6·NADHin + 0.6·Hnb + 0.4·H2Oin |
r41 | oxidative phosphorylation | NADHin + 0.5·O2nb + 3.5·Hnb + 2.5·ADPin + 2.5·Pnb | NADin + 3.5·H2Onb + 2.5·ATPin |
r42 | alpha-ketoglutarate synthesis | AKGnb | AKGin |
r43 | malic enzyme | MALin + NADPin | PYRin + CO2nb + NADPHin |
r44 | glutamate dehydrogenase | GLUin + H2Onb + NADin | AKGin + NH4nb + NADHin + Hnb |
r45 | lactate transport | LACin | LACex |
r46 | pyruvate transport | PYRin | PYRex |
r47 | glucose transport | GLCin | GLCex |
r48 | alanine transport | ALAex | ALAin |
r49 | serine transport | SERin | SERin |