Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells

Maier, Klaus; Hofmann, Ute; Reuss, Matthias; Mauch, Klaus

doi:10.1186/1752-0509-4-54

BMC Systems Biology

Table 4 Partial flux control coefficients for lactate dehydrogenase (r18) and oxidative phosphorylation (r41)

From: Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells

	r18					r41
	Partial flux control coefficient through					Partial flux control coefficient through
Enzyme	NAD_in	PYR_in	LAC_in	NADH_in	Flux control coefficient	ATP_in	NAD_in	ADP_in	NADH_in	Flux control coefficient
r1	0.011	0.032	-0.002	0.043	0.084	-0.012	0.001	-0.060	0.042	-0.028
r2	0.009	0.014	-0.001	0.038	0.059	-0.007	0.001	-0.034	0.037	-0.003
r3	0.011	0.017	-0.002	0.044	0.071	-0.008	0.002	-0.041	0.044	-0.005
r4	0.014	0.022	-0.002	0.056	0.089	-0.011	0.002	-0.052	0.055	-0.006
r5	0.002	0.003	0.000	0.008	0.012	-0.001	0.000	-0.007	0.008	-0.001
r6	0.032	0.050	-0.005	0.132	0.209	-0.025	0.005	-0.124	0.129	-0.015
r7	0.000	0.001	0.000	0.002	0.003	0.000	0.000	-0.002	0.002	0.000
r8	0.000	0.012	0.000	-0.002	0.009	-0.001	0.000	-0.005	-0.002	-0.008
r9	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000
r10	-0.142	-0.170	0.021	-0.584	-0.875	0.096	-0.020	0.476	-0.573	-0.021
r11	-0.006	-0.008	0.001	-0.027	-0.040	0.004	-0.001	0.022	-0.026	-0.001
r12	0.042	0.067	-0.007	0.173	0.275	-0.033	0.006	-0.163	0.169	-0.020
r13	-0.006	-0.010	0.001	-0.026	-0.041	0.005	-0.001	0.024	-0.026	0.003
r14	0.086	0.137	-0.014	0.352	0.561	-0.068	0.012	-0.331	0.345	-0.042
r15	-0.037	-0.059	0.006	-0.152	-0.242	0.029	-0.005	0.142	-0.149	0.017
r16	0.058	0.092	-0.009	0.237	0.377	-0.045	0.008	-0.222	0.233	-0.026
r17	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000	0.000
r18	0.041	-0.632	-0.014	0.168	0.564	-0.050	0.006	-0.250	0.165	-0.130
r19	-0.168	0.594	0.006	-0.693	-0.261	0.162	-0.024	0.805	-0.679	0.264
r20	0.001	0.001	0.000	0.003	0.005	0.000	0.000	0.001	0.003	0.005
r21	0.000	0.000	0.000	-0.001	-0.001	0.000	0.000	0.001	-0.001	0.000
r22	0.016	-0.037	-0.001	0.066	0.044	0.005	0.002	0.020	0.065	0.091
r23	0.000	0.001	0.000	0.000	0.001	0.000	0.000	0.000	0.000	0.000
r24	-0.003	-0.005	0.000	-0.013	-0.020	0.002	0.000	0.012	-0.013	0.001
r25	0.000	0.004	0.000	-0.002	0.002	0.000	0.000	0.002	-0.002	0.000
r26	0.000	0.000	0.000	-0.001	-0.001	0.000	0.000	0.001	-0.001	0.000
r27	0.001	0.001	0.000	0.002	0.004	0.000	0.000	-0.002	0.002	0.001
r28	0.001	-0.009	0.000	0.002	-0.006	0.001	0.000	0.004	0.002	0.007
r29	0.004	-0.125	0.002	0.017	-0.101	0.010	0.001	0.050	0.017	0.077
r30	0.005	-0.005	0.000	0.019	0.018	-0.002	0.001	-0.012	0.019	0.005
r31	0.008	-0.008	-0.001	0.035	0.034	-0.004	0.001	-0.022	0.034	0.009
r32	0.005	-0.005	0.000	0.021	0.020	-0.003	0.001	-0.013	0.020	0.006
r33	0.005	-0.008	0.000	0.022	0.020	-0.002	0.001	-0.008	0.022	0.013
r34	0.005	-0.007	0.000	0.021	0.018	-0.002	0.001	-0.008	0.020	0.012
r35	0.001	-0.036	0.001	0.005	-0.029	0.003	0.000	0.014	0.005	0.022
r36	0.014	-0.429	0.008	0.058	-0.348	0.035	0.002	0.171	0.057	0.265
r37	0.001	-0.001	0.000	0.003	0.003	0.000	0.000	-0.001	0.003	0.001
r38	-0.002	0.026	0.000	-0.008	0.016	-0.001	0.000	-0.007	-0.008	-0.016
r39	-0.022	0.018	0.002	-0.092	-0.094	0.008	-0.003	0.039	-0.090	-0.046
r40	0.009	-0.012	-0.001	0.035	0.031	-0.003	0.001	-0.013	0.034	0.020
r41	-0.043	0.954	-0.017	-0.176	0.718	-0.105	-0.006	-0.523	-0.172	0.193
r42	-0.019	-0.028	0.003	-0.078	-0.122	0.011	-0.003	0.054	-0.076	-0.014
r43	0.033	0.016	-0.004	0.137	0.183	-0.016	0.005	-0.081	0.135	0.042
r44	-0.008	0.054	0.000	-0.034	0.012	0.003	-0.001	0.016	-0.033	-0.015
r45	0.001	-0.015	0.024	0.004	0.014	-0.001	0.000	-0.006	0.004	-0.003
r46	0.036	-0.480	0.007	0.148	-0.289	0.025	0.005	0.122	0.145	0.297
r47	0.002	0.007	0.000	0.010	0.019	-0.003	0.000	-0.013	0.009	-0.006
r48	0.004	0.007	-0.001	0.016	0.026	0.002	0.001	0.008	0.015	0.025
r49	0.003	-0.043	0.001	0.010	-0.030	0.003	0.000	0.016	0.010	0.030

Partial flux control coefficients are only shown for metabolites having non-zero elasticities. The sum of the partial flux control coefficients for all intermediates equals the flux control coefficient. With regard to the control of an enzyme over its own flux, the flux control coefficient equals the sum of the partial flux control coefficients plus one.

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ISSN: 1752-0509

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