Spatio-temporal modeling of signaling protein recruitment to EGFR

BMC Systems Biology

Table 1 Docking rules for adaptors on EGFR cytoplasmic tails, as established by coarse-grained molecular docking modeling simulations

Plus (+) symbols on the same row indicate where docking simulations support the possibility for this combination of adaptors to simultaneously bind to phosphorylated tyrosine residues on the same EGFR tail. For example, from the first row, when Stat5 is bound to pY992, either one or both of PLCγ1 (pY1173) and Grb2 (pY1068) can bind simultaneously. Or, any or all of Shc (pY1148), Shc (pY1173), and Grb2 (pY1068) can bind simultaneously with Stat5 (pY992).

ISSN: 1752-0509