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Figure 1 | BMC Systems Biology

Figure 1

From: Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited

Figure 1

Reduced model of cell metabolism. Schematic representation of ATP generation pathways via aerobic glycolysis (glycolysis + pyruvate reduction to lactate) and oxidative phosphorylation (glycolysis + mitochondrial respiration). The variable f G , denotes the glucose uptake rate, f L and f M , the components of the glucose uptake routed towards lactate excretion and respiration, respectively, and f ATP the ATP production rate. Intermediate substrates of glucose catabolism are also used in a third process accounting for the production of precursor metabolites needed in anabolic processes (f P ). The pathways considered in our model are shown in the gray-shaded area, while f P is treated as constant.

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