Reduced model of cell metabolism. Schematic representation of ATP generation pathways via aerobic glycolysis (glycolysis + pyruvate reduction to lactate) and oxidative phosphorylation (glycolysis + mitochondrial respiration). The variable f
, denotes the glucose uptake rate, f
, the components of the glucose uptake routed towards lactate excretion and respiration, respectively, and f
the ATP production rate. Intermediate substrates of glucose catabolism are also used in a third process accounting for the production of precursor metabolites needed in anabolic processes (f
). The pathways considered in our model are shown in the gray-shaded area, while f
is treated as constant.