Characterization of major network communication properties. A. Relationship between node degree and traffic. B. A 3D contour plot of the communication and connectivity structure of the HF network. In A. a line is fitted to the data to highlight the linear relationship between the variables. In B. the black squares represent network proteins plotted against their corresponding degree values, and the colour-coded regions reflect the traffic levels. Colour regions and contours were fitted according to a distance weighted least squares procedure. The higher the position of a protein on the plot, the larger its number of connections and traffic level. Fibronectin 1 (FN1), integrin beta 1 (ITGB1) and platelet-derived growth factor receptor beta (PDGFRB) are the top three communication "hotpots" with the highest degree and traffic values in this network.