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Table 1 Overview of functional modules indentified through network structural analysis.

From: Coordinated modular functionality and prognostic potential of a heart failure biomarker-driven interaction network

Network module Number of proteins Number of interactions Median traffic Number of IMIs BP CC
1 33 87 64 2 Innate immune response (P = 2.0E-22) Extracellular region part (P = 5.1E-17)
2 17 57 32 3 Immune response (P = 5.0E-04) Cell part (P = 0.01)
3 21 84 40 12 Cell adhesion (P = 1.8E-06) Extracellular matrix part (P = 8.4E-14)
4 33 84 64 7 Circulation (P = 2.3E-19) Plasma membrane (P = 0.003)
5 32 94 62 7 Coagulation (P = 1.6E-08) Extracellular region part (P = 2.0E-04)
6 37 117 72 4 Tissue remodeling (P = 8.4E-05) Integral to plasma membrane (P = 0.005)
7 133 731 264 46 Cell adhesion (P = 2.7E-18) Extracellular region part (P = 9.9E-47)
8 11 26 20 1 Taxis (P = 1.9E-14) Plasma membrane part (P = 5.4E-06)
9 100 469 198 31 Protein digestion (P = 2.6E-13) Extracellular region part (P = 5.1E-33)
10 24 64 46 7 Positive regulation of signal transduction (P = 1.3E-05) ?
11 19 54 36 8 Proteolysis (P = 2.4E-13) Endoplasmatic reticulum (P = 0.004)
12 51 182 100 8 Immune response (P = 7.1E-13) Extracellular space (P = 0.002)
13 68 212 134 14 Cell adhesion (P = 4.4E-15) Receptor complex (P = 7.5E-12)
14 7 21 12 3 Cell adhesion (P = 2.0E-04) ?
15 18 42 34 4 Muscle contraction (P = 5.1E-05) Myofibril (P = 9.0E-04)
16 112 390 222 9 Cell communication (P = 7.7E-27) Cytoplasm (P = 0.007)
17 30 91 58 1 Response to stress* (P = 0.01) DNA-directed RNA polymerase complex* (P = 0.04)
  1. BP and CC are examples of biological processes and cellular localizations terms respectively, which are highly over-represented in each module, as defined in the GO. P values estimating the statistical significance, after correcting for multiple-testing, of the enrichment of the terms are also included. "*": enrichment of GO term in the module was nominally significant at P = 0.05, i.e., no statistical significance was observed after correcting P value for multiple-testing. "?": statistically detectable GO terms were not found. The numbers of interactions includes both inter- and intra-module interactions. Additional details are included in the Additional file 1 (Table S4). BP: biological process. CC: cellular component. IMIs: Inter-module interactions.