Table 1 Overview of functional modules indentified through network structural analysis.
Network module | Number of proteins | Number of interactions | Median traffic | Number of IMIs | BP | CC |
|---|---|---|---|---|---|---|
1 | 33 | 87 | 64 | 2 | Innate immune response (P = 2.0E-22) | Extracellular region part (P = 5.1E-17) |
2 | 17 | 57 | 32 | 3 | Immune response (P = 5.0E-04) | Cell part (P = 0.01) |
3 | 21 | 84 | 40 | 12 | Cell adhesion (P = 1.8E-06) | Extracellular matrix part (P = 8.4E-14) |
4 | 33 | 84 | 64 | 7 | Circulation (P = 2.3E-19) | Plasma membrane (P = 0.003) |
5 | 32 | 94 | 62 | 7 | Coagulation (P = 1.6E-08) | Extracellular region part (P = 2.0E-04) |
6 | 37 | 117 | 72 | 4 | Tissue remodeling (P = 8.4E-05) | Integral to plasma membrane (P = 0.005) |
7 | 133 | 731 | 264 | 46 | Cell adhesion (P = 2.7E-18) | Extracellular region part (P = 9.9E-47) |
8 | 11 | 26 | 20 | 1 | Taxis (P = 1.9E-14) | Plasma membrane part (P = 5.4E-06) |
9 | 100 | 469 | 198 | 31 | Protein digestion (P = 2.6E-13) | Extracellular region part (P = 5.1E-33) |
10 | 24 | 64 | 46 | 7 | Positive regulation of signal transduction (P = 1.3E-05) | ? |
11 | 19 | 54 | 36 | 8 | Proteolysis (P = 2.4E-13) | Endoplasmatic reticulum (P = 0.004) |
12 | 51 | 182 | 100 | 8 | Immune response (P = 7.1E-13) | Extracellular space (P = 0.002) |
13 | 68 | 212 | 134 | 14 | Cell adhesion (P = 4.4E-15) | Receptor complex (P = 7.5E-12) |
14 | 7 | 21 | 12 | 3 | Cell adhesion (P = 2.0E-04) | ? |
15 | 18 | 42 | 34 | 4 | Muscle contraction (P = 5.1E-05) | Myofibril (P = 9.0E-04) |
16 | 112 | 390 | 222 | 9 | Cell communication (P = 7.7E-27) | Cytoplasm (P = 0.007) |
17 | 30 | 91 | 58 | 1 | Response to stress* (P = 0.01) | DNA-directed RNA polymerase complex* (P = 0.04) |