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Table 2 Top-20 high-traffic proteins in the HF core network.

From: Coordinated modular functionality and prognostic potential of a heart failure biomarker-driven interaction network

Protein Network module BP CC Traffic
FN1 7 cell adhesion, response to wounding extracellular region 140037.9
PDGFRB 16 positive regulation of cell proliferation, positive regulation of cell migration ? 118789.9
ITGB1 13 homophilic cell adhesion, leukocyte adhesion cell surface 107208.2
C3 1 G-protein coupled receptor protein signaling pathway extracellular region 53979.1
COL1A1 7 blood vessel development plasma membrane 48837.3
TGFB1 6 connective tissue replacement during inflammatory response extracellular region 45861.8
MMP2 9 proteolysis extracellular space 43355.8
PTEN 17 regulation of cyclin-dependent protein kinase activity cytoplasm 43018.0
CHGB 17 ? ? 42398.0
ITGB3 7 blood coagulation integrin complex 41256.5
ADAM15 16 cell-matrix adhesion ? 36080.8
IL6ST 16 positive regulation of cardiac muscle hypertrophy interleukin-6 receptor complex 35295.1
COL2A1 7 collagen fibril organization collagen type II 33618.7
TNFSF11 9 immune response extracellular region 32703.6
ITGAV 9 cell adhesion cytoplasm 31291.3
PDGFRA 16 cell activation integral to plasma membrane 31130.0
LRP1 9 lipid metabolic process membrane fraction 30483.8
SRC 16 protein kinase cascade plasma membrane 28672.6
MMP9 9 macrophage differentiation extracellular space 27463.8
TNF 12 anti-apoptosis plasma membrane 27462.7
  1. Bold rows highlight proteins known to be HF biomarkers. For each protein, BP and CC represent examples of biological processes and cellular localization annotations respectively assigned to the protein, as defined in the GO. "?" means that no GO annotation was found for the protein (as of January 2009).