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Table 3 Differential gene expression of the top-20 high-traffic proteins between HF and non-HF patients.

From: Coordinated modular functionality and prognostic potential of a heart failure biomarker-driven interaction network

Protein t-statistic P Traffic
FN1 -0.99 NS 140037.9
PDGFRB 0.62 NS 118789.9
ITGB1 -0.44 NS 107208.2
C3 1.12 NS 53979.1
COL1A1 1.43 NS 48837.3
TGFB1 -1.98 0.06 45861.8
MMP2 0.16 NS 43355.8
PTEN -2.45 0.02 43018.0
CHGB 0.27 NS 42398.0
ITGB3 NA NA 41256.5
ADAM15 -0.21 NS 36080.8
IL6ST NA NA 35295.1
COL2A1 NA NA 33618.7
TNFSF11 NA NA 32703.6
ITGAV NA NA 31291.3
PDGFRA -0.65 NS 31130.0
LRP1 -0.37 NS 30483.8
SRC -0.54 NS 28672.6
MMP9 -1.15 NS 27463.8
TNF 1.39 NS 27462.7
  1. Bold rows highlight known HF biomarkers. t-statistic and P values of differential expression between HF and non-HF patients: 16 samples in each class. NS: Non-significant difference or difference statistically detectable at P > 0.1. 'NA': data not available in our expression dataset. A negative t-statistic means that the gene has a higher expression in the HF class.