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Table 3 Differential gene expression of the top-20 high-traffic proteins between HF and non-HF patients.

From: Coordinated modular functionality and prognostic potential of a heart failure biomarker-driven interaction network

Protein

t-statistic

P

Traffic

FN1

-0.99

NS

140037.9

PDGFRB

0.62

NS

118789.9

ITGB1

-0.44

NS

107208.2

C3

1.12

NS

53979.1

COL1A1

1.43

NS

48837.3

TGFB1

-1.98

0.06

45861.8

MMP2

0.16

NS

43355.8

PTEN

-2.45

0.02

43018.0

CHGB

0.27

NS

42398.0

ITGB3

NA

NA

41256.5

ADAM15

-0.21

NS

36080.8

IL6ST

NA

NA

35295.1

COL2A1

NA

NA

33618.7

TNFSF11

NA

NA

32703.6

ITGAV

NA

NA

31291.3

PDGFRA

-0.65

NS

31130.0

LRP1

-0.37

NS

30483.8

SRC

-0.54

NS

28672.6

MMP9

-1.15

NS

27463.8

TNF

1.39

NS

27462.7

  1. Bold rows highlight known HF biomarkers. t-statistic and P values of differential expression between HF and non-HF patients: 16 samples in each class. NS: Non-significant difference or difference statistically detectable at P > 0.1. 'NA': data not available in our expression dataset. A negative t-statistic means that the gene has a higher expression in the HF class.