(a) Breakdown of node class in the integrated pathway diagram and (b) Key to the pathway layout and content of the integrated diagram. (a) Components, Boolean Logic, Process Nodes and Edge Annotation form the category of possible nodes. A detailed breakdown of the number of each type of node in each category is given. (b) The key reflects the approximate location of the different pathway modules depicted in the integrated diagram (Figure 2). Ideally pathways with high connectivity and sharing identical components are spatially located in close proximity.