Figure 1

Genomic profiles of breast cancer cell lines. (A) Whole genome frequency analysis copy number gain (red), copy number loss (green), loss of heterozygosity/allelic imbalance (AI) (top blue) and copy number neutral LOH/AI (bottom blue). Vertical lines through all four graphs represent the genomic location of key breast cancer genes, using the hg18 build of the human genome map. (B) Illustration of copy number and LOH/AI status for ESR1, BRCA1, BRCA2, ERBB2 and TP53 in each of the samples. Each of these DNA events is evident in all of these genes.