Pathway analysis of the 1162 genes identified by multi-dimensional analysis. Ingenuity Pathway Analysis of the 1162 genes identified by MDA as well as genes meeting the same frequency criteria (6/9) from the analysis of the ten simulated datasets. In total, using the list of 1162 MDA genes, 53 canonical signaling pathways were identified as significant after multiple testing correction using a Benjamini-Hochberg correction (Additional File 5). In contrast, using the same statistical criteria, nine of the 10 simulated datasets yielded no significant pathways with one of the datasets yielding one pathway. In this figure, ten of the most well known, cancer-related pathways are shown. The yellow threshold line represents a Benjamini-Hochberg corrected p-value of 0.05 with bars above that line deemed significant. The first blue bar represents the analysis of the actual dataset and the subsequent ten bars represent the analyses of the ten simulated datasets.