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Figure 1 | BMC Systems Biology

Figure 1

From: Individual fates of mesenchymal stem cells in vitro

Figure 1

Noise driven differentiation dynamics. a) Modelling fluctuations of the differentiation state α. Upper panel: A decrease of the noise amplitude σ(α), i.e. the width of the Gaussian conditional probability function p(α|α'), with α results in an average drift to higher values of α. Lower panel: p(α|α') for α' = 0.4 and α' = 0.6. b) Noise amplitude for in vitro MSC expansion at 5% and 20% pO2. Proliferative states αp are shown in grey. c), d) Genealogies of expanding clones in the α-space of differentiation at 20% and at 5% pO2, respectively. α-trajectories of progeny arising from cell division are shown in individual colours.

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