Table 1 Parameter set used in the simulations
Parameter | Value |
|---|---|
Intracellular regulation | Â |
Randomization Rate R | 2.5 × 104 s-1 |
Stem Cell State Fluctuation Strength σ0 | 0.15 |
Hill Coefficient n | 5 |
Dissociation Constant k | 0.3 |
Differentiation Threshold αs (αd = 1-αs) | 0.85 |
Spatio-temporal organisation | Â |
Minimal Cell Radius R0 | 5 μm |
Minimal Cell Volume V0 | V(R0) |
Proliferation Rate r = 1/Ï„ | 1.9/day |
Young Modulus E | 450 Pa |
Contact Inhibition Threshold Fmax | 1 × 10-9 N |
Poisson's Ratio ν | 0.4 |
Friction Coefficients γij, γis | 3 × 107 Ns/m3 , 1 × 1011 Ns/m3 * |
Cellular Diffusion Coefficient DCell | 4 × 10-12 cm2/s |
Cell-Cell Anchorage ε | 6 × 10-5 N/m |
Cell-Plane Anchorage ε | 6 × 10-5 N/m |
Quiescence Threshold Fq | 10 N/m2 |