Correlation of measures of centrality. A) Degree, B) Closeness, C) Betweenness, D) Eccentricity with phenotypic similarity estimated by CIPHER Score. ρ represents Spearman's rho. The trend lines with negative slope in panels A, B and C indicate negative correlation of degree, closeness and betweenness with phenotypic similarity with the corresponding correlation coefficient and significance. The positive slope of the trend line in panel D demonstrates a positive correlation between eccentricity and phenotypic similarity. Thus, with the increasing phenotypic similarity, the respective disease associated genes show decreasing centrality. Very high degree values in the panel A have been removed in order to aid better visualization; however they have been considered for estimating correlation.