Figure 9

Networks of interactors of disease genes in disease tissues. A)Network of interactors of the phenodiv gene AKT1 which is associated with schizophrenia, ovarian cancer, colorectal cancer and breast cancer. The color of the nodes indicates the number of disease tissues in which the interactors are expressed in. As indicated by the co-expression of interactors, AKT1 interacts with diverse interactors under different pathological conditions. AKT1 as a specific example of phenodiv genes demonstrates that phenodiv genes have more interactors (higher connectivity) and show relatively restricted co-expression with their interactors across different tissues. Network of interactors of specific genes- B) CLINT1 C) RRAS2 D) PMS1 and E) PHB associated with schizophrenia, ovarian cancer, colorectal cancer and breast cancer respectively. As has been observed for the class of specific genes, CLINT1, RRAS2, PMS1 and PHB have lesser number of interactors and are co-expressed with all their interactors in the respective disease tissue.