Table 1 Comparison of measures of centrality of specific with shared genes and phenosim with phenodiv genes in human protein interaction network
From: Network properties of human disease genes with pleiotropic effects
Disease gene classes | Degree | Closeness | Betweenness | Eccentricity | ||||
|---|---|---|---|---|---|---|---|---|
|  | Mean ± S.D. | P-value * | Mean ± S.D. | P-value * | Mean ± S.D. | P-value * | Mean ± S.D. | P-value * |
Specific genes | 13.29 ± 24.21 | <0.001 | 0.26 ± 0.04 | <0.01 | 3.3 × 10-4 ± 0.001 | <0.001 | 8.65 ± 1.37 | <0.001 |
Shared genes | 16.28 ± 27.73 |  | 0.26 ± 0.03 |  | 5.9 × 10-4 ± 0.002 |  | 8.61 ± 1.06 |  |
Phenosim genes | 12.72 ± 20.72 | <0.001 | 0.27 ± 0.04 | <0.001 | 3.1 × 10-4 ± 0.0007 | <0.001 | 8.75 ± 0.88 | <0.01 |
Phenodiv genes | 20.44 ± 34.85 |  | 0.27 ± 0.04 |  | 8.7 × 10-4 ± 0.003 |  | 8.47 ± 1.17 |  |