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Table 1 Comparison of measures of centrality of specific with shared genes and phenosim with phenodiv genes in human protein interaction network

From: Network properties of human disease genes with pleiotropic effects

Disease gene classes Degree Closeness Betweenness Eccentricity
  Mean ± S.D. P-value * Mean ± S.D. P-value * Mean ± S.D. P-value * Mean ± S.D. P-value *
Specific genes 13.29 ± 24.21 <0.001 0.26 ± 0.04 <0.01 3.3 × 10-4 ± 0.001 <0.001 8.65 ± 1.37 <0.001
Shared genes 16.28 ± 27.73   0.26 ± 0.03   5.9 × 10-4 ± 0.002   8.61 ± 1.06  
Phenosim genes 12.72 ± 20.72 <0.001 0.27 ± 0.04 <0.001 3.1 × 10-4 ± 0.0007 <0.001 8.75 ± 0.88 <0.01
Phenodiv genes 20.44 ± 34.85   0.27 ± 0.04   8.7 × 10-4 ± 0.003   8.47 ± 1.17  
  1. *P-values were determined using Mann-Whitney U test