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Table 2 Comparison of measures of centrality of Essential genes with that of specific, shared, phenosim and phenodiv genes in human protein interaction network

From: Network properties of human disease genes with pleiotropic effects

Measure Essential Specific Shared Phenosim Phenodiv
  Mean ± S.D. P-value* P-value * P-value * P-value *
Degree 21.57 ± 35.89 <0.001 0.012 <0.001 0.44
Closeness 0.27 ± 0.03 <0.001 <0.001 <0.001 0.83
Betweenness 5.5 × 10-4 ± 0.002 <0.001 0.23 0.12 <0.001
Eccentricity 8.63 ± 0.87 <0.001 0.99 0.039 0.039
  1. Mean ± S.D. values for the specific, shared, phenosim and phenodiv genes are provided in Table 1. *P-values were determined using Mann-Whitney U test