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Table 2 Comparison of measures of centrality of Essential genes with that of specific, shared, phenosim and phenodiv genes in human protein interaction network

From: Network properties of human disease genes with pleiotropic effects

Measure

Essential

Specific

Shared

Phenosim

Phenodiv

 

Mean ± S.D.

P-value*

P-value *

P-value *

P-value *

Degree

21.57 ± 35.89

<0.001

0.012

<0.001

0.44

Closeness

0.27 ± 0.03

<0.001

<0.001

<0.001

0.83

Betweenness

5.5 × 10-4 ± 0.002

<0.001

0.23

0.12

<0.001

Eccentricity

8.63 ± 0.87

<0.001

0.99

0.039

0.039

  1. Mean ± S.D. values for the specific, shared, phenosim and phenodiv genes are provided in Table 1. *P-values were determined using Mann-Whitney U test
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BMC Systems Biology

ISSN: 1752-0509

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