Figure 2
From: The biological context of HIV-1 host interactions reveals subtle insights into a system hijack
A) Degree enrichment amongst HIV and randomised data sets. Distributions of enrichment scores (ES), from gene set enrichment analysis (GSEA), for the degree of 10,000 random samples taken from the population of protein-coding genes, rand (pop) (grey) and 10,000 randomised samples taken to match the publication count distribution of the HIV proteins rand (lit) (purple). The average ES amongst the rand (pop) sample is 0.69 (p-value of 8.90 × 10-48) whilst that of rand (lit) is 0.80 (p-value of 6.63 × 10-15). B) Betweenness enrichment amongst HIV and randomised data sets. Distributions of ES for the betweenness centrality of rand (pop) (grey) and rand (lit) (orange). The ES(betweenness) of the HIV-interacting proteins (red arrow) is 0.90 and the average amongst the rand (pop) sample is 0.84 (p-value of 1.98 × 10-21) whilst that of rand (lit) is 0.88 (p-value of 4.36 × 10-8).