Essentiality and HIV-interacting proteins. (A) Visualisation of essential proteins amongst HIV-interacting proteins. Green squares correspond to human proteins identified as essential from mouse knockout data. Black squares and red circles correspond to human and HIV proteins, respectively. Pink edges correspond to interactions between HIV-1 and human proteins, as shown in Figure 4. HIV proteins are labelled accordingly. (B) Number of essential proteins amongst HIV and randomised data sets. Without correcting for bias, rand
contained an average 143 (9.99%) essential proteins, compared to 376 (26.28%) essential proteins in the HIV set (p-value of 3.86 × 10-95). When the bias is corrected for, rand
contains an average 399 (27.88%) essential genes, whilst being under-represented, the result is not significant (p-value of 0.0574) and is hence similar to the HIV-1 interacting sample.