Disease association and topological properties of the human network. (A) Relationship between protein degree and disease-association. Protein degree and the percentage of disease-associated genes (blue) demonstrate a slight positive linear relationship (p-value of 0.02). Excluding overlapping essential genes from the disease-associated set (purple) removes the relationship (p-value of 0.29). (B) Relationship between protein betweenness centrality and disease-association. As for panel A, but for betweenness centrality. The percentage of disease-associated genes (blue) demonstrate a positive linear relationship with betweenness, (p-value of 0.01). Similarly excluding overlapping essential genes from the disease-associated set (orange) removes the relationships, (p-value of 0.45). (C) Relationship between publication count and disease-association. Disease-associated genes (green) have an average greater publication count than non-disease-associated genes (grey), 67 to 16 publications, respectively.