Protein degree (A) and betweenness centrality (B) for proteins involved in key cellular processes. The degree and betweenness centrality for proteins involved in the key over-represented biological processes GO terms from . Grey dashed lines correspond to the average degree (2.63) and betweenness centrality (2.33 × 10-5) amongst the human-human protein interaction network. The functionally over-represented proteins have a mean degree and betweenness of 7.27 and 7.40 × 10-5, respectively. P-values (from Wilcoxon rank-sum test) < 0.05 are indicated by an asterisk (*) above the data-points, suggesting the degree/betweenness distribution for each GO term is significantly different than that for all GO terms.