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Table 1 Annotation of genes identified in EDNRB network.

From: Protein interaction network topology uncovers melanogenesis regulatory network components within functional genomics datasets

Symbol Comments Motifs Z-score
EDNRB Endothelin receptor type B. Mutation causes Hirschsprung disease type 2 (HSCR2) [MIM:600155] 7tm_1 -1.1
GNA11 G-protein activates phospholipase C in endothelin pathway -1.9
EDN3 Ligand for endothelin receptor type B EDN 0.2
PLCD1 Phospholipase produces diacylglycerol and inositol 1,4,5-trisphosphate in endothelin pathway PH-PLC, C2_2, EFh -1.5
TAOK1 Kinase activates the p38 MAP kinase pathway in endothelin pathway SbcC, STKc_TAO -0.2
PTK2B Kinase regulates ion channel and activation of the MAP kinase signaling pathway in endothelin pathway PTKc_FAK, FERM_M. Focal_AT, B41, Pkinase_Tyr -1.9
AGTR1 Receptor for angiotensin II; defect causes renal tubular dysgenesis (RTD) [MIM:267430] 7tm_1 -1.7
RING1 E3 ubiquitin-protein ligase for histone H2A RING-finger 0.5
FHOD1 Required for the assembly of F-actin structures FH, GBD 0.2
DPYSL2 Signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton D-HYD -0.5
  1. Gene Ontology Database is used to assess function and identify conserved domains within the corresponding proteins. Z-scores are calculated based on the initial screen data [14].