Figure 3

Functional Gene Ontology annotations associated with the conserved eigensystems (A-D) Association of loadings of the conserved eigensystems with the functional annotations from the GO "biological process" ontology were analyzed by Wilcoxon sign rank test using RankGOstat [55]. Twenty GO terms most associated with a given eigensystem, and their association FDR q-values are shown as bar plots. For the plots the q-values were log10-transformed and multiplied by +1 or -1, to reflect association with the positive or negative loadings of a particular eigensystem. GO terms with overlapping meanings (identified by human inspection) are indicated by the same colour of the bars, with red marking terms related to "synaptic transmission", blue marking terms similar to "inflammatory response", and black marking terms describing cell death/apoptosis.