Figure 6

Effects of motifs binding AP1 and Satb1 on gene expression in the subspace of conserved eigensystem 2. The effects of motif count per gene on the loadings of the indicated eigensystem were analyzed by weighted linear regression. The response variable was the average loadings of a given eigensystem in groups of genes with the same count of the motif used as the regressor variable, with the weights equal to the numbers of genes per group. The average loadings for each motif count are indicated as blue dots, with their standard deviations shown as error bars, and the group gene count plotted next to each fitted data point. (A) The effect of SATB count on the loadings of eigensystem M2. (B) The effect of AP1F count on the loadings of eigensystem A2. (C) The effect of AP1F count on the loadings of eigensystem M2 analyzed for the genes without SATB motif. (D) The effect of AP1F count on the loadings of eigensystem M2 analyzed for the genes with SATB motif. (E-F) The log-expression profiles of Timp1 in the MCAO and kainate system. (G) A hypothetical mechanism, by which binding to the nuclear matrix via Satb1 makes a gene less accessible for binding or activation by AP1.