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Figure 6 | BMC Systems Biology

Figure 6

From: Robustness from flexibility in the fungal circadian clock

Figure 6

The model predicts that the positive loop promotes systematic entrainment in long days. A. The effect of varying the coupling strength of the positive feedback loop on conidiation phase ϕ FRQ . B. Conidiation phase dusk sensitivities ∂ϕ FRQ /∂t DUSK computed for short and long days (upper and lower plots respectively). In short days, ∂ϕ FRQ /∂t DUSK remains close to 0.5 as coupling strength is decreased, indicating systematic entrainment. In long days, however, ∂ϕ FRQ /∂t DUSK increases from 0.5 to 1 as positive feedback is abolished, quantifying the transition from an entrained to a (dusk-) driven rhythm that can be seen in A. This transition can be see in greater detail in Additional file 1, Figure S2B which shows the dependence of the sensitivity-photoperiod profile on positive feedback strength.

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