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Figure 5 | BMC Systems Biology

Figure 5

From: Fathead minnow steroidogenesis: in silico analyses reveals tradeoffs between nominal target efficacy and robustness to cross-talk

Figure 5

The response of the steroidogenesis model to increasing FAD exposure. GnRH introduces a pulse affect on LH. The oscillatory behavior at the LH receptor is filtered by the G-protein and PKA cycles and is significantly minimized by the time the signal reaches SF1. The cholesterol pool available inside the mitochondria is suppressed by FAD exposure. This leads to suppression of E2 and over production of T in the blood stream.

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BMC Systems Biology

ISSN: 1752-0509

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