Figure 7
Microarray data suggests that missing regulation involving (A) LH receptor up regulation, (B) Cytochrome P450c17αhydroxylase/17,20 lyase up regulation, or (C) inhibin down regulation may account for over production of T and E 2 during depuration. Each scenario was examined in the model by multiplying the appropriate parameter(s) with perturbations spanning three orders of magnitude. Neither up regulating P450 enzyme nor down regulating inhibin translation affected T or E2 production. Up regulating the translation of LH and/or increasing the available quantity of LH receptors both caused an increase in cholesterol translocation. This ultimately resulted in an over production of both E2 and T when compared to an unexposed fish (control).