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Table 1 Functional analysis of genes differentially expressed in ovaries during 24 hr fadrozole exposure

From: Fathead minnow steroidogenesis: in silico analyses reveals tradeoffs between nominal target efficacy and robustness to cross-talk

ENRICHED GO TERMS UP-REGULATED FOR FAD IN VITRO ENRICHED GO TERMS UP-REGULATED FOR FAD IN VIVO
GO Name p Value GO Name p Value
morphogenesis of an epithelium 0.011 pregnancy 0.009
protein amino acid glycosylation 0.029 ossification 0.012
glycoprotein biosynthesis 0.033 regulation of cell growth 0.012
biopolymer glycosylation 0.034 amino acid derivative catabolism 0.020
embryonic development (sensu Metazoa) 0.046 tissue development 0.021
glycoprotein metabolism 0.046 anti-apoptosis 0.027
   cell differentiation 0.029
   osteoblast differentiation 0.031
   development 0.036
   oogenesis 0.042
   reproductive physiological process 0.043
   nucleoside triphosphate metabolism 0.044
ENRICHED GO TERMS DOWN-REGULATED FOR FAD IN VITRO ENRICHED GO TERMS DOWN-REGULATED FOR FAD IN VIVO
GO Name p Value GO Name p Value
gastrulation 0.008 negative regulation of apoptosis 0.002
DNA replication 0.009 anti-apoptosis 0.003
cellular carbohydrate metabolism 0.016 negative regulation of programmed cell death 0.003
carbohydrate metabolism 0.019 purine ribonucleotide biosynthesis 0.004
potassium ion transport 0.021 pregnancy 0.006
macromolecule biosynthesis 0.023 nucleoside triphosphate metabolism 0.007
glucose catabolism 0.025 transcription from RNA polymerase II promoter 0.009
hexose catabolism 0.026 regulation of physiological process 0.012
monosaccharide catabolism 0.026 signal transduction 0.013
positive regulation of cellular process 0.026 purine nucleoside triphosphate biosynthesis 0.015
alcohol catabolism 0.027 nucleoside triphosphate biosynthesis 0.016
physiological process 0.028 G-protein signaling, coupled to cyclic nucleotide second messenger 0.020
energy derivation by oxidation of organic compounds 0.032 reproductive organismal physiological process 0.021
mitochondrial transport 0.033 nucleoside metabolism 0.024
positive regulation of biological process 0.035 reproductive physiological process 0.024
glucose metabolism 0.036 energy coupled proton transport, down electrochemical gradient 0.024
protein amino acid glycosylation 0.040 ATP synthesis coupled proton transport 0.024
muscle contraction 0.042 regulation of cellular physiological process 0.026
protein biosynthesis 0.043 cell-cell adhesion 0.027
glycoprotein biosynthesis 0.044 cell proliferation 0.031
carbohydrate catabolism 0.044 regulation of programmed cell death 0.038
cellular carbohydrate catabolism 0.044 apoptosis 0.038
biopolymer glycosylation 0.045 G-protein signaling, coupled to cAMP nucleotide second messenger 0.038
cellular process 0.046 development 0.040
  1. **The full list of significant GO terms are in Additional File 1.