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Figure 5 | BMC Systems Biology

Figure 5

From: Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death

Figure 5

Consequences of impaired caspase feed-back on spatial anisotropies during apoptosis execution. (A) The end-to-end delays in onset of substrate cleavage (1%) as well as the delays for half maximal substrate cleavage by effector caspases were calculated in absence of positive feedback from caspase-3 onto caspase-9 p35/p12. In parallel, diffusivity was modified across 5 orders of magnitude. (B) End-to-end delays from the non-perturbed reference model were subtracted from the results displayed in (A). Negative values represent reduced spatial anisotropies due to inhibition of feed-back of caspase-3 onto caspase-9 p35/p12. (C) The end-to-end delays in onset of substrate cleavage (1%) as well as the delays for half maximal substrate cleavage by effector caspases were calculated in absence of caspase-3 auto-processing. In parallel, diffusivity was modified across 5 orders of magnitude. (D) End-to-end delays from the non-perturbed reference model were subtracted from the results displayed in (C). Negative values represent a reduction in spatial anisotropies due to inhibition of caspases-3 auto-processing.

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