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Table 1 Noise and haploinsufficiency in different loop structures

From: The role of noise and positive feedback in the onset of autosomal dominant diseases

Network Type Network Type a b c
1 X deficient
Y deficient
0
+
0
-
+
+
2 X deficient
Y deficient
++
+
-
+
++
+
3 X deficient
Y deficient
0
++
++
++
0
++
  1. Effect of Gaussian noise and haploinsufficiency on disease dynamics with different positive feedback loop structures. ++ indicates early, irreversible and severe disease onset; + indicates disease onset is variable and slightly suppressed; - are cases where disease fluctuates randomly, but reversibly and is suppressed as soon as the appropriate protein rises or falls; 0 indicates no disease occurs.