Network Type | Network Type | a | b | c |
---|
1 | X deficient Y deficient | 0 + | 0 - | + + |
2 | X deficient Y deficient | ++ + | - + | ++ + |
3 | X deficient Y deficient | 0 ++ | ++ ++ | 0 ++ |
- Effect of Gaussian noise and haploinsufficiency on disease dynamics with different positive feedback loop structures. ++ indicates early, irreversible and severe disease onset; + indicates disease onset is variable and slightly suppressed; - are cases where disease fluctuates randomly, but reversibly and is suppressed as soon as the appropriate protein rises or falls; 0 indicates no disease occurs.