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Table 1 Noise and haploinsufficiency in different loop structures

From: The role of noise and positive feedback in the onset of autosomal dominant diseases

Network Type

Network Type

a

b

c

1

X deficient

Y deficient

0

+

0

-

+

+

2

X deficient

Y deficient

++

+

-

+

++

+

3

X deficient

Y deficient

0

++

++

++

0

++

  1. Effect of Gaussian noise and haploinsufficiency on disease dynamics with different positive feedback loop structures. ++ indicates early, irreversible and severe disease onset; + indicates disease onset is variable and slightly suppressed; - are cases where disease fluctuates randomly, but reversibly and is suppressed as soon as the appropriate protein rises or falls; 0 indicates no disease occurs.