Skip to main content

Table 2 Sensitivity of feedback loop to changes in stochasticity parameters

From: The role of noise and positive feedback in the onset of autosomal dominant diseases

Trial Expression level Noise stdev Time scale (days) Penetrance Mean onset
1b 50% 0.2 2 0.31 2.1/5.9
2 50% 0.5 2 0.94 22.1/20.4
3 50% 1.0 2 1.0 12.5/10.6
4 50% 0.2 5 0.91 21.9/21.8
5c 52.5% 0.5 2 0.20 6.1/18.7
6 52.5% 1.0 2 0.95 17.8/15.9
7d 52.5% 0.5 5 0.54 7.5/13.0
8 52.5% 1.0 5 1.0 22.0/18.5
9 55% 0.5 2 0.0 --
10 55% 0.5 5 0.0 --
11e 55% 1.0 2 0.34 8.8/19.2
12 55% 1.0 5 1.0 2.7/0.1
13f 60% 1.0 5 0.0 --
  1. Sensitivity of feedback loop 2.a to changes in stochasticity is illustrated here using 100-trial simulations. Expression level is such that 50% is at the critical level: slightly lower expression, with no noise, allows disease to deterministically occur all the time. 100 simulations for each set of conditions were run to compute a penetrance value. When no noise is present, the system is deterministic and no disease occurs as long as the base expression level is 50% or higher. When expression is 60% or higher, no disease occurs even with the highest level of random variation used in this study.