From: The role of noise and positive feedback in the onset of autosomal dominant diseases
MODY type | Gene deficiency | Prevalence(1) | Treatment(1,2) | Simulated mean/std of onset age | Simulated mean/std insulin |
---|---|---|---|---|---|
1 | Hnf-4α | Uncommon | Oral medication or insulin | 10.3/1.2 | 0.18/0.02 |
2 | glycokinase | Common | Diet and exercise | 4.5/0.3 | 0.26/0.005 |
3 | Hnf-1α | Most common | Oral medication or insulin | 24.0/8.1 | 0.24/0.08 |
4 | Pdx1 | Rare | Oral medication or insulin | 22.6/11.0 | 0.22/0.11 |
5 | Hnf-1β | Rare | Insulin | 9.3/0.4 | 0.08/0.004 |