Table 1 Model parameters
From: Stress-specific response of the p53-Mdm2 feedback loop
Parameter | Default value | Effect of stresses | |
|---|---|---|---|
σ | p53 production | 1000 nM.hr-1 | Ribonucleotide depletion ↗ |
α | Mdm2-independent | 0.1 hr-1 | |
degradation/deactivation of p53 | |||
δ | Mdm2-dependent | 11 hr-1 | DNA damage, Hypoxia, |
degradation/deactivation of p53 | Oncogene, Nitric Oxide: all ↘ | ||
k t | Mdm2 transcription | 0.03 nM-1hr-1 | Hypoxia ↘ |
k tl | Mdm2 translation | 1.4 hr-1 | |
B | Mdm2 mRNA degradation | 0.6 hr-1 | |
γ | degradation/deactivation of Mdm2 | 0.2 hr-1 | DNA damage ↗ |
k b | p53-Mdm2 dissociation | 7200 hr-1 | |
k D = k b /k f | p53-Mdm2 dissociation constant | 1.44 nM | Nutlin ↗, DNA damage ↗ |