Figure 4
From: Predicting functional associations from metabolism using bi-partite network algorithms
Performance comparison, local vs. global methods. The best local method, the Poisson score incorporating metabolite degree, is compared with global methods based on graph diffusion with and without edge weights accounting for multiple reactions for each enzyme. The global methods perform better, and weighted and unweighted diffusion kernels have equivalent performance. (A) ROC curve. (B) PR curve.