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Table 3 Mean values of centrality measures on HDFs and on proteins of the whole human protein interaction network, with standard deviations between brackets.

From: Identifying potential survival strategies of HIV-1 through virus-host protein interaction networks

μ (σ) HDF network total human network P v a l u e k s (HDF > total)
degree 16 (25) 6 (11) 2.42·10-97
betweenness 63·103 (19·104) 17·103 (79·103) 9.22·10-63
eigenv. centr. 0.049 (0.10) 0.013 (0.04) 3.08·10-87
  1. P v a l u e k s is calculated from a one-sided Kolmogorov-Smirnov test with alternative hypothesis: HDF network > total human network regarding degree, betweenness and eigenvector centrality. In the HDF network each node has approximately three times more connections (16 in HDF vs 6 in the total human network), four times higher betweenness (63·103 in HDF vs 17·103 in human) and a four times higher eigenvector centrality score (0,049 in HDF vs 0,013 in human). The significant higher centrality of the HDF sub-network shows that it takes on a central position within the total human protein interaction network.