Construction and application of a human phenome-microRNAome network. (A) Construction of a functionally related microRNA network. An edge is placed between two microRNAs if they share significant number of target genes. (B) Application of the phenome-microRNAome network to infer new microRNA-disease associations. A gray edge connects known disease-related microRNA to the corresponding disease. Disease 2 has a related microRNA (miR-6), and disease 4 doesn’t have any related microRNAs. The red dash lines represent the potential microRNA-disease associations that might be predicted by this network model.