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Figure 2 | BMC Systems Biology

Figure 2

From: Prioritization of disease microRNAs through a human phenome-microRNAome network

Figure 2

Functionally related microRNAs tend to be associated with Phenotypically similar diseases. (A) The observed average phenotypic similarity score (arrow) of 349 phenotype pairs associated with common microRNAs and the distribution of expected average phenotypic similarity scores (curve) of 10,000 random control sets containing the same number of randomly sampled phenotype pairs (p<10-4). (B, C) The observed average functional relatedness (arrow) of 1,252 microRNA pairs associated with common diseases and the distribution of the expected average functional relatedness (curve) of 10,000 random control sets containing the same number of randomly sampled microRNA pairs (p<10-4). The measures for functional relatedness between microRNAs are the average number of shared network neighbors and a function value that is derived from the shortest path length.

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