The structure of the dynamic network in the exit-entry updating process During the exit-entry updating process, a vacated vertex is replaced by a new macrophage according to the fitness function determined by its neighbouring cells. An original network is shown in the left part of Figure 1 (Left). If a cell, marked in gray, exits the network, the possibility of replacing this cell with either a type C (classically activated macrophage) or type A (alternatively activated macrophage) cell is determined by the fitness function of the neighbouring cells. Cost function of each cell linked to the vacated cell is shown in the middle of the figure (Middle). In this case, the fitness function of all type C cells is calculated as F
= 4(1 − ω)+ ω(10a + 2b). Similarly, the fitness function determined by the connected type C cells can be calculated as F
= 4(1 − ω)+ ω(3c + 5d). The gray vertex may be replaced by a type A cell with probability , or a type C cell with probability of according to the exit-entry evolutionary strategy, which is shown in the right part of Figure 1 (Right).