Non-compartment model to compartment model pharmacokinetics transformation meta-analysis – a multivariate nonlinear mixed model

Table 1 Summary of Published Non-Compartment Model Midazolam Pharmacokinetics Parameters

Non-Compartment PK Parameters	Reported	Missed
C _max	9	1
AUC	10	0
T _max	7	3
T _1/2,fast	2	8
T _1/2,slow	8	2
V _d	5	5
CL _iv	4	6

There are totally 10 studies available from publications. This table shows the number of reported and missed records for the sample means of non-compartment PK parameters among those 10 studies.

ISSN: 1752-0509