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Table 2 Midazolam Compartment Model Pharmacokinetics Parameter Estimates

From: Non-compartment model to compartment model pharmacokinetics transformation meta-analysis – a multivariate nonlinear mixed model

Compartment Model PK Parameters Non-Compartment Model to Compartment Model Transformation  
  Fixed-Effect  
  log-scale raw-scale Between Study CV*
V 1 3.5 33.11 10%
k a 0.68 1.97 84%
k 12 -1.1 0.33 -
k 21 -1.32 0.27 -
k e -0.403 0.67 23%
Within-Study CV**   27%  
  1. These compartment model PK parameters are estimated from reported non-compartment model PK parameters. *These are between-study variances for compartment model PK parameters. **This is the within-study variance for all non-compartment PK parameters.