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Table 2 Midazolam Compartment Model Pharmacokinetics Parameter Estimates

From: Non-compartment model to compartment model pharmacokinetics transformation meta-analysis – a multivariate nonlinear mixed model

Compartment Model PK Parameters

Non-Compartment Model to Compartment Model Transformation

 
 

Fixed-Effect

 
 

log-scale

raw-scale

Between Study CV*

V 1

3.5

33.11

10%

k a

0.68

1.97

84%

k 12

-1.1

0.33

-

k 21

-1.32

0.27

-

k e

-0.403

0.67

23%

Within-Study CV**

 

27%

 
  1. These compartment model PK parameters are estimated from reported non-compartment model PK parameters. *These are between-study variances for compartment model PK parameters. **This is the within-study variance for all non-compartment PK parameters.