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Table 3 Simulation Results with No Missing Data

From: Non-compartment model to compartment model pharmacokinetics transformation meta-analysis – a multivariate nonlinear mixed model

  

Estimate

  
  

TRUE(log-scale)

Mean

SE

RelativeBias (%)

95% CP

 
 

V 1

3.5

3.505

0.110

0.14

0.89

 
 

k a

0.68

0.680

0.115

0.02

0.87

 

Fixed-Effect

k e

-0.403

-0.397

0.112

0.75

0.89

 
 

k 12

-1.1

-1.097

0.088

0.24

0.93

 
 

k 21

-1.32

-1.322

0.053

0.15

0.99

 
 

V 1

0.09

0.083

0.045

8.05

0.97

 

Between Study Variance

k a

0.09

0.078

0.053

12.8

0.93

 
 

k e

0.09

0.085

0.045

5.33

0.96

 

Sigma 2

 

0.01

0.01

0.003

4.43

0.95