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Table 4 Simulation Results with Missing Data

From: Non-compartment model to compartment model pharmacokinetics transformation meta-analysis – a multivariate nonlinear mixed model

  

Estimate

  
  

TRUE(log-scale)

Mean

SD

RelativeBias (%)

95% CP

 
 

V1

3.5

3.494

0.129

0.17

0.92

 
 

ka

0.68

0.672

0.159

1.13

0.87

 

Fixed-Effect

ke

-0.403

-0.389

0.141

2.84

0.90

 
 

k12

-1.1

-1.09

0.172

0.59

0.84

 
 

k21

-1.32

-1.323

0.070

0.19

0.99

 
 

V1

0.09

0.081

0.052

9.82

0.98

 

Between Study Variance

ka

0.09

0.082

0.066

9.43

0.95

 
 

ke

0.09

0.087

0.055

3.60

0.97

 

Sigma 2

 

0.01

0.01

0.003

13.9

0.96