Skip to main content

Advertisement

Table 4 Simulation Results with Missing Data

From: Non-compartment model to compartment model pharmacokinetics transformation meta-analysis – a multivariate nonlinear mixed model

   Estimate   
   TRUE(log-scale) Mean SD RelativeBias (%) 95% CP  
  V1 3.5 3.494 0.129 0.17 0.92  
  ka 0.68 0.672 0.159 1.13 0.87  
Fixed-Effect ke -0.403 -0.389 0.141 2.84 0.90  
  k12 -1.1 -1.09 0.172 0.59 0.84  
  k21 -1.32 -1.323 0.070 0.19 0.99  
  V1 0.09 0.081 0.052 9.82 0.98  
Between Study Variance ka 0.09 0.082 0.066 9.43 0.95  
  ke 0.09 0.087 0.055 3.60 0.97  
Sigma 2   0.01 0.01 0.003 13.9 0.96